New Study: Peers into Brains of Adults with Autism to Understand Sensory Abnormalities

December 10, 2021

New Study: Peers into Brains of Adults with Autism to Understand Sensory Abnormalities

Scientists find evidence for links between differences in brain morphology and atypical visual, taste, and smell characteristics in autistic people

People with autism spectrum disorder (ASD) tend to exhibit sensory abnormalities, such as hypersensitivity or insensitivity to visual or auditory stimuli. In a recent study, researchers from University of Fukui, Japan and Korea Brain Research Institute used brain imaging to find relationships between differences in brain morphology and sensory abnormalities in ASD individuals. Their findings could enable a better understanding of the underlying neurological basis for ASD symptoms, opening doors to better diagnostics and treatment.

Autism spectrum disorder (ASD) is a condition involving atypical brain development that affects behavior, communication, and learning. People with ASD often have trouble functioning in certain contexts and adjusting socially, and tend to engage in restrictive and repetitive behaviors. Although remarkable progress has been made over the past few decades in how ASD cases are diagnosed and handled, the underlying neurological basis responsible for the main features of ASD remains a mystery.

Could the ways ASD individuals perceive the world hold clues about the key differences in their brains? It is not news to scientists that people with ASD exhibit sensory abnormalities, such as sensory hypersensitivity, insensitivity, or avoidance, depending on the type of stimuli. In fact, sensory abnormalities are now regarded as a core symptom in the diagnostic guidelines for ASD, and specialists have linked them to the social impairment features typical of ASD individuals. Additionally, brain imaging can shed some light on the neurological basis of ASD. Scientists have linked differences in brain morphology¡ªthe volume and shape of the different brain regions¡ªto specific social impairments. However, very few studies have focused on the relationship between the sensory aspects of ASD and brain morphology.

In a recent study published inTranslational Psychiatry, a team of researchers from Japan and South Korea sought to address this knowledge gap. Led by Professor Hirotaka Kosaka from University of Fukui, Japan, the team recruited 43 adults with ASD and 84 adults with neurotypical development, and performed magnetic resonance imaging (MRI) scans of their brains. They used a specialized software to automatically quantify various morphological features of brain anatomy with high accuracy. They also had all recruited individuals fill in the Adolescent/Adult Sensory Profile (AASP), a self-reported questionnaire that is widely used to assess a person¡¯s behavioral response patterns to sensory stimuli and symptoms.

The researchers first looked for differences in brain morphology and AASP scores between the neurotypical and ASD groups and then investigated if there were any statistical relationships between the shape or volume of specific brain regions and sensory characteristics. ¡°We found marked correlations between the visual characteristics and the thickness of the orbitofrontal and lingual cortices as well as between the taste/smell characteristics and the hippocampal volume in adults with ASD,¡± remarks Professor Kosaka. ¡°Therefore, it¡¯s possible that structural changes in the brains of adults with ASD may cause sensory abnormalities.¡±

Overall, the results provide some evidence that alterations in brain morphology could be responsible, at the neurological level, for the sensory abnormalities commonly found in ASD individuals. Taken together with the results from previous studies, they extend our knowledge of how different sensory abnormalities contribute to the social impairments that affect ASD individuals.

From a ×ãÇò±È·Ö_ÀºÇò±È·Ö-²¨µ¨|Ö±²¥ practical standpoint, these findings could benefit both ASD individuals and their families, as Dr. Habata explains: ¡°The burden on family members caring for ASD individuals is enormous, and many of them suffer from anxiety. In clinical settings, giving such families an appropriate diagnosis and sharing information related to the disease can provide them a sense of relief. By understanding that ASD symptoms could arise from structural problems in the brain, families will be less likely to blame themselves for poor parenting.¡± From a ×ãÇò±È·Ö_ÀºÇò±È·Ö-²¨µ¨|Ö±²¥ technical standpoint, MRI could help diagnose ASD better, as Dr. Jung, principal investigator of KBRI, explains: ¡°Magnetic resonance imaging is a non-invasive technique for gathering highly accurate anatomical information of the brain. It could, therefore, help us better understand ASD symptoms that occur in brain.¡±

The study could pave the way for better diagnostic options for ASD beyond behavioral indicators, the only criteria used today. If further research confirms that specific brain regions are consistently involved in the pathogenesis of ASD, its diagnosis and even treatment could become easier.

Let us hope that day is not too far.

Brain imaging as a tool to study autism spectrum disorders.
Brain imaging techniques are being widely used to find clues about the underlying neurological causes of autism spectrum disorders. Now, researchers from University of Fukui, Japan and Korea Brain Research Institute, Korea have shed new light on this front that could enable better diagnostics and treatment options.
Photo courtesy: Dr. Kaie Habata from University of Fukui.

Reference
Title of original paper:Relationship between sensory characteristics and cortical thickness/volume in autism spectrum disorders
Journal Translational Psychiatry
DOI:10.1038/s41398-021-01743-7

Additional requirements for EurekAlert
Latest Article Publication Date: 06 December 2021
Method of Research: Imaging analysis
Subject of Research: People
Conflicts of Interest (COI) Statement: The authors declare no competing interests.

About University of Fukui, Japan
The University of Fukui is a preeminent research institution with robust undergraduate and graduate schools focusing on education, medical and science, engineering, and global and community studies. The university conducts cutting-edge research and strives to nurture human resources capable of contributing to society on the local, national, and global level.

Website: /eng/

About Korea Brain Research Institute, South Korea
The Korea Brain Research Institute (KBRI) is a world-leading research institute in convergence brain science. One of the goals of KBRI is the establishment of a creative brain research ecosystem through the development of core fundamental technology in brain research.

Website: https://www.kbri.re.kr/new/pages_eng/main/

About Professor Hirotaka Kosaka from University of Fukui, Japan
Hirotaka Kosaka obtained a PhD in Medicine from Fukui Medical University, Japan, in 2004. He joined the Faculty of Medical Sciences at the University of Fukui in 2005 as a Research Associate. He then moved to the Research Center for Child Mental Development at the University of Fukui in 2012 as an Associate Professor, and became a Full Professor in 2014. He specializes in psychiatry, neuroscience, neuroimaging, functional MRI, and autism spectrum disorders. He has published over 285 papers and has authored 8 books on these subjects.

About Senior Researcher from Korea Brain Research Institute, Korea
Minyoung Jung obtain a PhD from Osaka University, Japan, in 2015. He opened the brain development imaging LAB at Korea Brain Research Institute as Principal Investigator in 2021. He specializes in neuroimaging, child development, neuropsychology, and structural MRI.

About Doctor Kaie Habata from University of Fukui, Japan
Kaie Habata graduated from the School of Medical Sciences, University of Fukui, Japan, in 2016. As a psychiatrist, he is engaged in clinical practice of neuropsychiatric disorders, and entered the Graduate School of Medical Sciences (doctoral program), University of Fukui, in 2018. Now, he has been conducting the neuroimaging researches on neurodevelopmental disorders, such as autism spectrum disorders in the field of psychiatry.

Funding Information
This study was supported by the KBRI basic research program through the Korea Brain Research Institute funded by the Ministry of Science and ICT (21-BR-05-02), as well as the Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (18K15481, 20H01766, 20K07916, and 20H04272).

Media contact:
Mika Hayashi
sskoho-k¡ùad.u-fukui.ac.jp

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